Report: There is strong evidence that physical activity has various benefits on health in primary, secondary and tertiary prevention. However, studies on the socio-economic impacts of Health-Enhancing Physical Activity (HEPA) still remains scant, particularly in the French context. The aim of this report was to explore the grey and scientific literature to identify studies evaluating the socio-economic impacts of HEPA policies and to put forward some research perspectives. Based on twenty studies conducted in France, this report showed that reducing sedentary behavior and promoting of HEPA might generate substantial savings. Nevertheless, new studies must leaded to estimate more precisely the extent of the savings that could be generated according to the environments and populations targeted by HEPA policies.